Oral STAT3 Inhibitor, TTI-101, in Patients With Advanced Cancers
Status:
Recruiting
Trial end date:
2023-10-01
Target enrollment:
Participant gender:
Summary
Many patients have cancers that have increased activity of a protein called STAT3 that
contributes critically to the development and growth of their cancer. Despite our knowledge
of STAT3's importance to cancer, scientists and doctors have not developed a drug that
targets it and that patients can take to treat their cancer more effectively than treatments
that are now available. Tvardi Therapeutics, Incorporated has developed a compound, TTI-101,
which can be given by mouth and acts as a direct inhibitor of STAT3. Administration of
TTI-101 to mice demonstrated that it blocked growth of cancers of the breast, head and neck,
lung, and liver and it was safe when administered at high doses to mice, rats, and dogs. In
this application, Tvardi is proposing to further develop TTI-101 for treatment of solid
tumors for which the prognosis is dismal. The investigators will determine how safe it is
when administered to patients with cancer, determine whether an adequate dose can be
administered to patients with cancer that will block STAT3 in their cancer, and determine
whether treatment with TTI-101 leads to reduced growth of their cancer.
Phase:
Phase 1
Details
Lead Sponsor:
StemMed, Ltd., USA Tvardi Therapeutics, Incorporated