Oral Olanzapine Versus Haloperidol or Diazepam

• Status: Terminated
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether oral olanzapine is safer (fewer adverse events) and more effective (shorter time to sedation) than conventional haloperidol or diazepam when used in the management of acute agitation in the emergency.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Hong Kong
• Collaborator: Queen Elizabeth Hospital, Hong Kong
• Treatments: Diazepam; Haloperidol; Haloperidol decanoate; Olanzapine

Criteria

Inclusion Criteria:

• Accident & Emergency Department patients

• Requiring oral drug sedation (as determined by an emergency clinician) will be enrolled.

Exclusion Criteria:

• known hypersensitivity or contraindication to the study drugs

• reversible aetiology for agitation (e.g. hypotension, hypoxia, hypoglycaemia)

• known pregnancy

• acute alcohol withdrawal

• refusal to take oral medication

• patients from correctional facilities