Oral Nifedipine Versus IV Labetalol in Severe Pre Eclampsia
Status:
Unknown status
Trial end date:
2018-01-15
Target enrollment:
Participant gender:
Summary
OBJECTIVE: To determine the efficacy of nifedipine and labetalol in terms of control of BP in
pre eclamptic pregnant patients
Design: Randomised control trial
SETTING: Department Obstetrics & gynaecology, Services Hospital, Services Institute of
Medical Sciences. Lahore
POPULATION: Pregnant patients with BP 160/110 or symptoms of severe preeclampsia
METHODS: Patients are randomised to receive nifedipine (10 mg tablet, orally, up to five
doses) and intravenous placebo saline injection or intravenous labetalol injection (in an
escalating dose regimen of 20, 40, 80, 80 and 80 mg) and a placebo tablet every 15 minutes
until the target blood pressure of ≤140/90mmHg is achieved. Crossover treatment is given if
the initial treatment regimen is unsuccessful