Oral Melatonin as Premedication During MAC for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation

• Status: Completed
• Trial end date: 2018-11-07
• Target enrollment: 0
• Participant gender: All

Summary

investigators assume that administration of preoperative melatonin will reduce the required dose of propofol in participants undergoing loco-regional chronic subdural hematoma evacuation, it may as well provide better postoperative analgesia and decrease the incidence of delirium.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• 50 -65 years

• ASA grade I to II

• Both sexes

• Patients with unilateral chronic subdural hematoma

• Patients who are vitally stable

• Glascow coma scale 14-15

Exclusion Criteria:

• Age below 50 and above 65 years.

• Gastro intestinal tract impractabililty.

• Patients with any substance abuse.

• Patients with hepatic or renal insufficiency.

• Patients on antipsychotic, anticonvulsant or anti-parkinsonian medication.

• Vitally unstable patients who cannot tolerate propofol sedation.

• Patients with known allergies to any of the drugs used.