The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks
provided in mid-pregnancy to obese subjects will decrease the plasma ADMA/L-arginine ratio,
lower maternal blood pressure, improve endothelial-dependent vascular function and peripheral
vascular stiffness, and improve uterine artery Doppler resistance and flow.
Phase:
Phase 1
Details
Lead Sponsor:
University of Pittsburgh
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)