Oral Cholecalciferol in Prevention of Type 2 Diabetes Mellitus
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Type 2 diabetes mellitus (T2DM) is a major public health problem .Prevalence of vitamin D
deficiency is also high i.e. 78-96% in different groups of population in north India.
Observational studies find association between low Vitamin D status and type 2 diabetes
mellitus. Prediabetes is a condition that progress to diabetes at a rate of 6-10% per year
.There is mechanistic support that vitamin D may influence both insulin secretion and insulin
sensitivity and subsequently T2DM incidence. In general, cross-sectional and prospective
studies support the role of vitamin D in the prevention of T2DM. This study will be a single
blind randomized placebo controlled trial to study the effect of oral cholecalciferol in
insulin sensitivity and secretion in adults with prediabetes who are also vitamin D
insufficient.
Phase:
Phase 4
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research