Oxidative stress is one of the main mechanisms causing harm in severe infection with septic
shock, ischemia-reperfusion injury in resuscitated cardiac arrest and ischemic and
hemorrhagic stroke.
Melatonin is a potent scavenger of the mediators of oxidative stress, oxygen and
nitrogen-reactive species, which directly injure cell structures like walls and DNA and thus
cause organ dysfunction.
In a previous study we have observed that high-dose oral bedtime melatonin (OBM) is
associated with improved organ function in severe Covid-19 patients