Oral Azithromycin Versus Doxycycline in Posterior Blepharitis
Status:
Completed
Trial end date:
2013-07-01
Target enrollment:
Participant gender:
Summary
One hundred patients with the diagnosis of posterior blepharitis based on history taking and
proper physical examinations by two experienced ophthalmologists will include in the study.
Patients will diagnose with posterior blepharitis if they score at least one in two symptoms
(based on a subjective grading scale) and two signs (based on an objective grading scale) of
posterior blepharitis according to study criteria. Patients will exclude if they have the
following criteria: age< 12 years old,history of previous ocular or lacrimal surgery,previous
usage of contact lenses,any history of ocular allergy,history of systemic diseases with
ocular involvement (except rosacea), history of usage of topical or systemic antibiotic in
the last month, pregnancy or lactating mothers, liver failure and any history of sensitivity
to cyclines.
Qualified patients then randomly receive oral azithromycin (2 of 250 mg capsules for the
first day and 250mg for the next 4 days) or oral doxycycline (100mg capsule every 12 hours
for one month) in a double-blinded fashion. each patients in both treatment groups will
accurately instruct to apply warm compress and eyelid scrubbing 2 times a day for 5 minutes
each in the treatment period. Symptoms and signs were recorded for each patient in two
treatment groups at baseline visit (before treatment) and then in the days 7, 31, 37 and 61
after treatment.