Oral Antibiotic Outpatient Therapy vs. Placebo in the Treatment of Uncomplicated Acute Appendicitis
Status:
NOT_YET_RECRUITING
Trial end date:
2045-12-01
Target enrollment:
Participant gender:
Summary
APPAC IV, a randomized double-blind multicenter clinical trial comparing once daily oral moxifloxacin with placebo in an outpatient setting aims to evaluate whether antibiotics and hospitalization or both can be omitted in the treatment of uncomplicated appendicitis further significantly increasing cost savings and patient satisfaction. This is a direct research continuum to the previous trial triad: APPAC, APPAC II and APPAC III, which have already established that the majority of patients with uncomplicated acute appendicitis can be safely treated without surgery. The APPAC IV trial is based on a novel concept and approach to further optimize the nonoperative treatment of uncomplicated acute appendicitis with a high potential in resulting in major health care cost savings and potentially also in significant reduction of antibiotic use in an extremely common surgical emergency.
Phase:
NA
Details
Lead Sponsor:
Turku University Hospital
Collaborators:
Jyväskylä Central Hospital Kuopio University Hospital Mikkeli Central Hospital Oulu University Hospital Päijänne Tavastia Central Hospital Pori Central Hospital Seinajoki Central Hospital Tampere University Hospital