Oral Anti-Infective Agent for Esophageal Anastomotic Leakage

• Status: Unknown status
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Anastomotic leakage is still to be a major cause of considerable morbidity and mortality after esophagectomy and gastric pull up for esophageal carcinoma. Risk factor analyses of anastomotic leakage, including blood supply, graft tension, and comorbidity, have been performed, but few studies have produced strategies that have improved operative results. This study will be performed to identify prognostic variables that might be used to develop a strategy for optimizing outcomes after esophagogastrectomy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Anti-Infective Agents; Nystatin

Criteria

Inclusion Criteria:

• carcinoma of the esophagus, operable stage I to III

Exclusion Criteria:

• patients who were inoperable,

• patients who had obvious impaired blood supply of gastric substitutes, and

• patients who had non-cervical esophagogastrostomy.