Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors (SSRIs) in Treatment-Resistant Depression

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will determine the effectiveness of adding S-adenosyl methionine to antidepressant drug treatment in reducing depressive symptoms in depressed people who have not responded to antidepressants alone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Serotonin; Serotonin Uptake Inhibitors

Criteria

Inclusion Criteria:

• Major depressive disorder

• Use of an SSRI for at least 6 weeks prior to study entry with partial or no response

Exclusion Criteria:

• History of psychosis

• Allergy to SAMe

• Alcohol or drug abuse in the past 3 months prior to study entry