Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Status:
RECRUITING
Trial end date:
2028-12-31
Target enrollment:
Participant gender:
Summary
Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in allergic patients is based on side chain chemical similarity and limited skin testing evidence. This project includes a clinical trial and mechanistic studies to optimize the approach to cephalosporin allergy and advance future diagnostics.
Phase:
PHASE2
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)
Treatments:
Ampicillin benzylpenicilloyl G polylysine Cefaclor Cefadroxil Cefazolin Cefdinir Cefepime Cefixime Cefotaxime Cefpodoxime Ceftazidime Ceftriaxone Cefuroxime Cephalexin Histamine Monobactams Penicillin G