Overview

Optimized Treatment of Peginterferon Alfa 2a/2b in Treatment Experienced Patients With HBV Related Liver Fibrosis

Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
0
Participant gender:
All
Summary
Compared to nucleoside/nucleotide analogues, peginterferon alfa 2a/2b may has more therapeutic efficacy in hepatitis B surface antigen or e antigen seroconversion and anti-tumor occurrence in chronic hepatitis b patients. We design this study to investigate treatment of peginterferon alfa 2a/2b in anti-virus treatment experienced patients with HBV related liver fibrosis.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Third Affiliated Hospital, Sun Yat-Sen University
Treatments:
Interferon-alpha
Peginterferon alfa-2a
Peginterferon alfa-2b
Tenofovir
Criteria
Inclusion Criteria:

1. Positive hepatitis b surface antigen or hepatitis b virus DNA > 0.5 year;

2. Age from 18 to 55 years old;

3. Fibrosis lever of F1 to F3 from liver biopsy; if liver biopsy unreachable, fibrosis
lever of 7 to 14 kpa from fibroscan;

4. Portal vein diameter ≤ 12 mm from liver ultrasound;

5. Receiving treatment of nucleoside/nucleotide analogues at the past one year;

6. Normal liver function;

7. Undetectable hepatitis b virus DNA.

Exclusion Criteria:

1. Decompensated cirrhosis, hepatocellular carcinoma or other malignancy;

2. Pregnancy or lactation;

3. Other active liver diseases;

4. Human immunodeficiency virus infection or congenital immune deficiency diseases;

5. Severe diabetes, autoimmune diseases;

6. Other important organ dysfunctions;

7. Patients can not follow-up;

8. Investigator considering inappropriate.