Optimal Treatment of MRSA Throat Carriers

• Status: Recruiting
• Trial end date: 2022-12-30
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate the optimal way to treat MRSA throat carriers.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hvidovre University Hospital
• Treatments: Clindamycin; Clindamycin palmitate; Clindamycin phosphate

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• MRSA carriage in the throat after first topical decolonization treatment (regardless of previous swab results)

• Has completed one standard topical decolonization treatment

Exclusion Criteria:

• Pregnant or lactating woman

• Sexually active women in the reproductive age that do not use approved contraceptives (appendix 4)

• Cannot read or speak Danish (the written participant information is in Danish)

• Skin infection or other active infections

• Activity in skin diseases such as eczema or psoriasis.

• MRSA isolate resistant to clindamycin (defined by inhibition zone size < 22 mm using disk diffusion methodology) or resistant to mupirocin

• Allergy to clindamycin, chlorhexidine or mupirocin

• Taking medications that interact with clindamycin according to the medicine information leaflet.

• MRSA active antibiotic treatment within 7 days before inclusion in the study or during study period

• Followed by specialist due to liver disease

• Severe overweight (BMI > 35) or weight < 50 kg

• Indwelling percutaneous permanent devices such as intravenous catheters or urinary tract catheters

• Daily contact with pigs or minks (decolonization therapy is generally not offered, according to The National Board of Health)

• Nursing home resident or health care worker (they have a more frequent control swab regime)

• Not being capable of completing another treatment successfully

• MRSA positive household members younger than 2 years (MRSA positive children below 2 years of age and their household members are generally not offered decolonization treatment according to The National Board of Health)

• MRSA positive household members, where it is judged that further decolonization attempts are not indicated