Optimal Treatment for Poor Efficacy of Entecavir in Chronic Hepatitis B Patients

• Status: Not yet recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: All

Summary

There are chronic hepatitis B patients with poor antiviral efficacy of entecavir in clinical practice. Tenofovir or interferon alfa is the optimal choice right now. The aim of this study is to investigate the therapeutic effect of using tenofovir of interferon alfa in these patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Third Affiliated Hospital, Sun Yat-Sen University
• Treatments: Entecavir; Interferon alpha-2; Interferon-alpha; Interferons; Tenofovir

Criteria

Inclusion Criteria:

1. Hepatitis b virus DNA or HBsAg positive for over half a year;

2. Age from 18 to 65;

3. With poor efficacy of entecavir: Hepatitis b virus DNA is still positive at 24 weeks, and decrease > 2 lg from baseline .

4. Not be treated with interferon alfa ever before.

Exclusion Criteria:

1. Other active liver diseases;

2. Cirrhosis, hepatocellular carcinoma or other malignancy;

3. Pregnancy or lactation;

4. Human immunodeficiency virus infection or congenital immune deficiency diseases;

5. Severe diabetes, autoimmune diseases;

6. Other important organ dysfunctions;

7. Patients can not follow-up.