Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses

• Status: Completed
• Trial end date: 2016-04-01
• Target enrollment: 0
• Participant gender: Male

Summary

Intubation is a procedure that requires well relaxed muscles while general anesthesia is performed. In order to get adequate muscle relaxation, remifentanil, sevoflurane or both agents in combination have been reported as they can provide adequate conditions for laryngoscopy and tracheal intubation without using muscle relaxants.

However, there were no previous studies to find the effective dose of sevoflurane in combination with different bolus doses of remifentanil to obtain adequate endotracheal intubation conditions without using muscle relaxants. The aim of this study is to investigate the change in the minimum sevoflurane alveolar concentration which produces an adequate endotracheal intubation condition when sevoflurane is combined with different bolus doses of remifentanil used in clinical practice.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Severance Hospital
• Collaborator: Armed Forces Capital Hospital, Republic of Korea
• Treatments: Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists physical status I or II who were scheduled to undergo elective otolaryngological surgery

Exclusion Criteria:

• history of reactive airway disease

• smoking hx.

• a predictive signs of difficult intubation

• body mass index ≥ 30 kg•m-2 or ≤ 15 kg•m-2