Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved(Frozen)-Thawed Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone.

• Status: Completed
• Trial end date: 2019-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of the study is to determine whether 5 or 7 days of progesterone supplementation before transfer of a day 5 cryopreserved thawed embryos in an artificial cycle results in a significant higher pregnancy rate.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universitair Ziekenhuis Brussel
• Treatments: Estradiol valerate; Estrogens; Progesterone

Criteria

Inclusion Criteria:

• Artificial cycles, in which a frozen-thawed day 5 embryo is replaced.

• Signed informed consent.

• Normal transvaginal ultrasound at screening, without evidence of clinically significant abnormality consistent with finding adequate for ART with respect to uterus and adnexa.

• Embryos must be frozen by vitrification technique (cfr supra).

• Single or dual embryo transfer.

• Recipients of oocyte donation cycles may be included.

Exclusion Criteria:

• Known allergic reactions to progesterone products.

• Intake of experimental drug within 30 days prior to study start.

• Contraindication for pregnancy.

• Embryos of women above 39 years of age at the time of embryo freezing.