Optimal Dosing of Preoperative Gabapentin for Prevention of Postoperative Nausea and Vomiting
Status:
Completed
Trial end date:
2021-02-15
Target enrollment:
Participant gender:
Summary
Overall incidence of postoperative nausea and vomiting (PONV) after general anesthesia is
40-90 % . gabapentin has been incorporated into "fast-track" packages and improved recovery
during surgery protocols to avoid unintended side effects associated with opioid
alternatives. Interestingly, gabapentin has also been noted to reduce the effects of
chemotherapy-induced nausea, effective in treatment of gravidarum hyperemesis, and postdural
puncture emesis. Different dosing regimens were tested.The goal of the study is to determine
the most effective dose of oral gabapentin given 1 hour prior to surgery on the occurrence
and severity of PONV and drug side effects in the first 24 hours postoperatively to find the
most effective dose of gabapentin with the least side effects.