Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children

• Status: Completed
• Trial end date: 2012-08-01
• Target enrollment: 0
• Participant gender: All

Summary

There is a wide variation of published IV ketamine dosing regimens used for procedural sedation in children in the Emergency Department (ED). The purpose of the study was to compare the efficacy, duration of sedation and adverse events between the three commonly administered doses of IV ketamine (1 mg/kg, 1.5 mg/kg and 2 mg/kg) using the traditional administration method of 30-60 second infusion for ED sedation in children.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Hospital of Michigan
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Children 3 -18 years of age

• Belonging to American Society of Anesthesiologists (ASA) classification 1 or 2

• Receiving IV ketamine for procedural sedation for orthopedic procedures,

• Incision and Drainage of skin abscess and laceration repair

Exclusion Criteria:

• Contraindications to use of Ketamine

• Parents or legal guardian not available or declined to provide informed consent

• Child declined to provide assent,

• Patients that received intramuscular ketamine,

• Patient that received benzodiazepines in addition to ketamine

• Children weighing >100 kilogram

• Children with developmental disabilities.