Optimal Dose of Combination of Rocuronium and Cisatracurium
Status:
Completed
Trial end date:
2015-02-01
Target enrollment:
Participant gender:
Summary
BACKGROUND: The combinations of rocuronium and cisatracurium have a synergic effect. The
investigators studied whether the prediction is possible to have a sufficient effect of
reducing the dose when combining the two neuromuscular blocking agents through monitoring
neuromuscular relaxation during surgery.
METHODS: Each group were intubating dose group (Group I, n=27) combined Effective Dose (ED)95
rocuronium and ED95 cisatracurium, small amount reducing group (Group S, n=27) reduced 10% of
each ED95 and large amount reducing group (Group L, n=27) reduced 20% of each ED95. Before
patients arrived in the operating room, rocuronium and cisatracurium were prepared by a nurse
who was not involved in this study. Each study drug was administrated to the patient and
timer was started with TOF-Watch® monitoring. Train-of-four (TOF) of the ulnar nerve was used
as setting of 2 Hz per 12 sec. The investigators checked time to TOF ratio=0 (Onset), time to
1st TOF ratio>25% (Duration 25%) and TOF 25-75% (recovery index) under total i.v. anesthesia
(TIVA). One way ANOVA was used for statistical analysis (α=0.05, β=0.2).