Optimal Administration of Allopurinol in Dialysis Patients
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
Gout has a strong association with the metabolic syndrome, and it is often seen in patients
with renal insufficiency. Allopurinol is a medication intended to lower uric acid and
therefore prevents gout attacks. Its metabolism is mainly renal, and some evidence shows that
it is also dialyzable. The hypothesis is that allopurinol would be more efficacious to lower
uric acid if it was given after dialysis only. The investigators will then switch
administration of allopurinol to bedtime for dialysis patients currently taking that
medication.