Opioids Withdrawal Syndrome in Critically Ill Patients: a Multicenter Prospective Cohort Study
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Critically ill patients who are mechanically ventilated may require prolonged administration
of sedatives and analgesics. Their prolonged use has been associated with withdrawal symptoms
upon rapid weaning in critically ill patients. These withdrawal symptoms may be associated
with adverse clinical outcomes. Although well studied in the paediatric population, little is
known about the epidemiology, risk factors and optimal screening methods in adults. Studying
this problem is essential as we strive to develop proper weaning strategies.
Methods: Prospective observational two-center study in critically ill adult patients
Objectives: 1) Describe the incidence of iatrogenic withdrawal of sedatives and analgesics in
critically ill adult patients and 2) Evaluate the performance of screening tools assessing
withdrawal that were developed for the paediatric patient in the adult population.