Opioid and Cannabinoid Pharmacokinetic Interactions
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
We are conducting a study to assess whether smoking marijuana affects the safety of
prescribed opioids in patients treated for chronic pain. This study will assess whether
smoking cannabis affects the absorption, distribution, metabolism and excretion of widely
used opioid analgesics. We propose to do this by investigating the effects of smoked cannabis
in subjects prescribed morphine or oxycodone for chronic pain. We will also assess the
clinical safety of cannabinoids and these opioids by monitoring the short-term side effects
associated with combined therapy.