Opioid Use in Single Shot Nerve Block vs Continuous Peripheral Nerve Infusion in Anterior Cruciate Ligament (ACL) Repair

• Status: Terminated
• Trial end date: 2015-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Anterior cruciate ligament repair using hamstring autograft in children is a painful orthopedic procedure. The current practice to provide analgesia for this procedure include femoral continuous perineural infusion and femoral single shot peripheral nerve block, along with perioperative opioids and NSAIDS both IV and orally. Since the use of opioids can be associated with adverse side effects, which include, but are not limited to nausea, vomiting, constipation, pruritus and respiratory depression, comparing the amount of opioid used with either analgesia delivery method is needed.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Hospital of Philadelphia
• Treatments: Bupivacaine

Criteria

Inclusion Criteria:

• American Society of Anesthesiology (ASA) physical status 1 or 2

• Male or female subjects ages 14 to 18 years old at time of procedure

• Patients who undergo an ACL repair using the hamstring autograft at The Children's Hospital of Philadelphia

• Parental/guardian permission (informed consent) and if appropriate, child assent

Exclusion Criteria:

• Parents/patients refusal to the placement of a femoral and/or sciatic nerve block

• Contraindications to femoral and/or sciatic nerve block:

1. Infection

2. Neurologic deficits, including motor and/or sensory deficit of the femoral and sciatic nerves.

• Patients' inability to participate in pain scoring because of developmental delay.

• Performance of an all-epiphyseal ACL repair.

• Allergy to any of the medications used in the study.

• Presence of a coagulopathy