Opioid-Induced Swallowing Dysfunction - The Impact of Bolus Volume
Status:
Unknown status
Trial end date:
2018-04-01
Target enrollment:
Participant gender:
Summary
The purpose of the study is to evaluate the impact of different bolus volumes and viscosity
on remifentanil-induced swallowing dysfunction in healthy volunteers.Hence, whether
swallowing tasks can be done safer during sedation by altering bolus volumes and viscosities
will be revealed. Furthermore, the study will clarify underlying mechanisms (central vs.
peripheral effects) of remifentanil-induced swallowing dysfunction. If methylnaltrexone
reverses the remifentanil-induced effects on swallowing, this would suggest a dominant
peripherally mediated mechanism.