Opioid Induced Hyperalgesia (OIH) Modulation With Propranolol
Status:
Unknown status
Trial end date:
2017-05-01
Target enrollment:
Participant gender:
Summary
Opioid Induced Hyperalgesia (OIH) is an entity than has been demonstrated in healthy
volunteers and in animal models. Is defined as an increase in the perception to painful
stimuli, increasing the opioid requirements and diminishing the pain thresholds to stimuli.
The apparition of OIH is also related to the exposure to opioids during surgery, depending of
the dose, the time of exposition and the type of opioid.
This condition can be modulated, specially in the perioperative context. It has been seen in
healthy volunteers and in animal models, than the use of propranolol can modulate this
phenomena, diminishing the postoperative requirements of analgesia. It is also unknown, the
dose of propranolol required to modulate adequately OIH.
The objective of this work is to evaluate the efficacy of propranolol in the modulation of
opioid induced hyperalgesia, with lower postoperative requirements of analgesia rescue.