Opioid Free VS Opioid Anesthesia for Craniotomies

• Status: Completed
• Trial end date: 2021-10-03
• Target enrollment: 0
• Participant gender: All

Summary

Hemodynamic control during craniotomies can be a bit hectic specially during periods of intense noxious stimulation. For long anesthesiologists used high doses of opioids such as fentanyl and remifentanyl to provide analgesia with a good hemodynamic control during intraoperative period in patients undergoing craniotomies. However, the use of opioids was not devoid of side effects. Exploring other anesthetic plans using multiple opioid free anesthetic adjuvants that have analgesic effects given together in small doses appear to be appealing plan. This idea is the basis of our proposed study in which we compare the hemodynamic effects of using opioid free anesthesia versus opioid anesthesia in cranial surgeries.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kasr El Aini Hospital
• Treatments: Analgesics, Opioid; Anesthetics

Criteria

Inclusion Criteria:

• ASA Ι and II.

• Patients undergoing surgeries for removal of supratentorial tumors.

• Age (18-60) years.

• Both sexes.

Exclusion Criteria:

• Impaired renal functions.

• Systemic hypertension.

• Dysrhythmia.

• Heart failure.

• Glasgow coma scale less than 12.

• The need for postoperative ventilation.

• History of allergy to the study drugs.

• Surgeries lasting more than 6 hours.

• Pregnancy.

• Bronchial asthma