Opioid Effects on Swallowing Comparing Younger and Elderly Volunteers

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to determine whether remifentanil influence the pharyngeal phase of swallowing using using pressure and impedance recordings. The purpose is also to compare remifentanil to morphine and younger to elderly volunteers.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Region Örebro County
• Treatments: Morphine; Remifentanil

Criteria

Inclusion Criteria:

• 18-30 or 65 < year old healthy volunteers from both sexes.

• Have signed and dated Informed Consent.

• Willing and able to comply with the protocol for the duration of the trial.

Exclusion Criteria:

• Pharyngoesophageal dysfunction

• Known history of cardiac, pulmonary or neurological disease

• Ongoing medication

• Allergies to or history of reaction to remifentanil, fentanyl analogues or other ingredients

• Pregnancy or breast feeding

• BMI > 30

• Previous participation in a medical clinical trial where opioid has been used or have during last 30 days participated in any other medicinal clinical trial or in a trial where follow-up in not complete.