Open Label Study: Treatment of ALS Fatigue With PolyMVA
Status:
Completed
Trial end date:
2021-05-25
Target enrollment:
Participant gender:
Summary
Amyotrophic lateral sclerosis (ALS) is a disease that causes the death of upper and lower
motor neurons. ALS symptoms are characterized by stiffness, muscle twitching, and worsening
weakness due to muscle breakdown. Onset of symptoms are typically arm or leg weakness or
difficulty speaking or swallowing and gradual development of overall body weakness. The cause
is unknown and there is no cure for ALS.
Poly MVA was found to substantially lower fatigue and improve quality of life in a pilot
study of patients with varied medical disorders. The reduction in fatigue was also observed
in a small series of patients enrolled in an open label study for patients with gliomas.
In this study, we want to find out more about a dietary supplement, called Poly MVA (also
called the study drug in this form), for people with ALS. We want to find out if Poly MVA
reduces the symptoms of fatigue and depression when taken daily. The supplement contains
vitamins, minerals and amino acids (proteins) and has been used by patients with other
medical conditions to help with their fatigue and quality of life.