Onset Time of Thiopental Versus Propofol in the Elderly

• Status: Completed
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is aimed at increasing the safety of the use of anaesthesia in an elderly population (> 60 years). Patients with decreased physiological reserve, including all elderly patients, have an increased risk of getting an erroneous induction bolus. This project will investigate how fast elderly patients (> 60 years) fall asleep during bolus induction of anaesthesia with two of the most used hypnotics, thiopental and propofol, evaluated with BIS-monitoring and clinical signs of anaesthetic depth. The hemodynamic response will also be evaluated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rigshospitalet, Denmark
• Collaborator: TrygFonden, Denmark
• Treatments: Propofol; Thiopental

Criteria

Inclusion Criteria:

• Elective surgical patients above 60 years of age, with an indication of general anaesthesia during surgery.

• Informed consent.

• The patient must be legally competent.

• The patient must be able to read and understand Danish.

Exclusion Criteria:

• Known allergic reactions to thiopental, propofol, lidocaine or alfentanil

• "Body Mass Index" (BMI) <18 and > 35.

• NYHA-class > 2.