One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators
Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
Participant gender:
Summary
One-lung ventilation; organ protection; volatile anesthetics
One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis
will be tested in this study:
1. Are inflammatory mediators increased in the re-ventilated lung after short-period
pulmonary collapse?
2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated
lung? Therefore, this study will elucidate the potential protective effect of a volatile
anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory
compartment of the lung, i.e. the alveolar epithelium.
- Trial with immunomodulatory product / biological