Overview

Ondansetron vs Prochlorperazine for Nausea and Vomiting in the Emergency Department

Status:
Completed
Trial end date:
2008-09-01
Target enrollment:
0
Participant gender:
All
Summary
This study will compare the effect of prochlorperazine and ondansetron for the treatment of nausea and vomiting in the emergency department.
Phase:
Phase 2
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Emory University
Treatments:
Ondansetron
Prochlorperazine
Criteria
Inclusion Criteria:

- Patients presenting to the ED with at least one of the following

- Nausea

- Vomiting documented in the ED

Exclusion Criteria:

- Previous treatment in the ED with Ondansetron, prochlorperazine, promethazine or
metaclopramide

- Patients with missed last menstrual period

- Pregnancy

- Age < 18 years old

- Treatment with antineoplastic agents within 7 days prior to randomization

- Irritable bowel syndrome

- Gastroparesis

- Suspected gastrointestinal bleed

- Suspected intestinal obstruction

- Preexisting motor disorder (Restless-leg syndrome or Parkinson's disease)

- Traumatic brain injury upon admission to ED

- Intracranial hemorrhage upon admission to ED

- Patients unable to read, write or communicate in the English language

- Patients leaving the ED against medical advice