Ondansetron Effect on Pain Relief After Laparoscopic Cholecystectomy
Status:
Completed
Trial end date:
2020-12-18
Target enrollment:
Participant gender:
Summary
Laparoscopic cholecystectomy (LC) is an easy procedure characterized by its minimal
invasiveness, less post-operative pain and early recovery when compared to the open
conventional cholecystectomy. However, patients who have undergone LC still complain of
postoperative pain. It has been reported that ondansetron produces numbness when injected
under the skin and has local anesthetic effect that is 15 times more potent than lidocaine
the most widely used local anesthetic and probably explains its antiemetic action. It
possesses anti-inflammatory, anesthetic, and analgesic properties by its multifaceted actions
as a 5-HT3 receptor antagonist, a Na channel blocker, and a mu-opioid agonist which may have
a potential role in decreasing pain. The study aimed to demonstrate the effectiveness of IP
administration of ondansetron on pain management post LC.
Phase:
Phase 2
Details
Lead Sponsor:
National Hepatology & Tropical Medicine Research Institute