Once Weekly Infant Corticosteroid Trial for DMD

• Status: Recruiting
• Trial end date: 2024-12-30
• Target enrollment: 0
• Participant gender: Male

Summary

The hypothesis tested here is that a lower dose of intermittent oral corticosteroids (5mg/kg/week) will be equally effective to the 10mg/kg/week dose.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Anne M. Connolly
• Collaborators: Ann & Robert H Lurie Children's Hospital of Chicago; Children's Hospital Medical Center, Cincinnati
• Treatments: Prednisolone

Criteria

Inclusion Criteria:

• Subjects ages 1 month through 30 months

• Weakness consistent with Duchenne on exam, creatine kinase ≥ 20 times the upper limit of normal, and genetic mutation known to be causative for DMD.

Exclusion Criteria:

• Prior treatment with Glucocorticosteroids