Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
Status:
NOT_YET_RECRUITING
Trial end date:
2027-06-01
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections). These medications-tissue plasminogen activator (tPA) and deoxyribonuclease (DNase)-are placed through a chest tube into the space between the lung and the chest wall to help clear out the infection.
The investigators are trying to learn:
* Does using the medicine once a day work just as well as using it twice a day?
* Are there any differences in outcomes between patients who get the medicine once a day versus twice a day?
* Does more or less fluid remain in the chest (seen on a chest x-ray) depending on how often the medicine is given?
Participants will:
* Have an infection around their lung and will already be getting normal hospital care, including a chest tube to drain the infected fluid around their lung.
* Be asked to give permission to join the study.
* Be randomly chosen (like flipping a coin) to get the medications either once a day or twice a day through the chest tube.