Once-Daily Amikacin Plus Cloxacillin in Febrile Neutropenic Children
Status:
Completed
Trial end date:
2004-06-01
Target enrollment:
Participant gender:
Summary
Once-daily dose administration of aminoglycoside in adults is effective and economical.
However, its value in febrile neutropenic children, especially in Thailand, is less well
researched. In the area where Pseudomonas aeruginosa prevalence in febrile neutropenic
children is low, the combination of cloxacillin and amikacin is an appropriate approach. This
study would like to compare the efficacy and safety including cost between these two amikacin
administrations (once-daily or twice-daily) in combination with cloxacillin as an empirical
therapy in febrile neutropenic children.
Hypothesis: Once-daily amikacin plus cloxacillin can be used to treat febrile neutropenic
children in Khon Kaen, Thailand.