Traumatic brain injury (TBI) is major health problem that stands as a significant cause of
death and permanent disability. TBI is considered as global public health epidemic. On
pathophysiologic basis, TBI is described as occurring in two phases, primary and secondary.
Once a primary insult occurs like trauma or ischemia, the secondary injury begins though main
four mechanisms; ischemia, brain edema, axonal injury and neuro-inflammation. Omega-3 PUFAs
(Polyunsaturated fatty acids) are postulated to have neuroregenerative properties with the
ability to impact all four main mechanisms of the secondary injury Patients will be allocated
into one of two groups through a random table generation; Control group in which patients
will follow our local protocol for TBI management without SMOF-lipid infusion. SMOF-lipid
group in which patients will receive 0.5 g/Kg SMOF lipid 10% emulsion (Lipid emulsion for
intravenous nutrition containing; 6% soybean oil / 6% medium chain triglycerides / 5% olive
oil / 3%fish oil) daily over 12 hours starting once admitted to ICU for 7 days