Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder
Status:
Completed
Trial end date:
2011-03-01
Target enrollment:
Participant gender:
Summary
The primary objective of the study was to determine the effects of 10-week adjunctive
supplementation with 2 doses of LCn-3 fatty acids (fish oil) on cortical functional activity
and biochemistry in adolescents with MDD.
The primary prediction was that LCn-3 fatty acid supplementation would dose-dependently
increase prefrontal cortical functional activation during sustained attention and increase
regional biochemical indices of cortical metabolism and integrity concentrations in
association with reductions in depressive symptoms.