Pain after acute burn injury is complex with much still not understood. The primary mechanism
is believed to be nociceptive, but is interwoven with aspects of somatogenic, neuropathic,
and psychogenic pathways. As such, opioid receptor agonists are an essential component for
pain management after burn injury. The majority of wound care and dressing changes are
completed in non-intubated patients and rates of respiratory depression concerning.
Oliceridine is a biased, selective MOR agonist approved for treatment of acute pain. To date
there is no literature of use in patients with burn injuries. While it should be effective,
efficacy and the potential for reduced adverse events need to be quantified. Current practice
and guidelines, plead for better analgesia for patients with burn injuries.