This research study is for patients with metastatic breast cancer.
- Metastatic means that the cancer has spread beyond the breast. In addition, through
genetic testing of the blood or tumor, an altered gene has been found that suggests the
tumor may not be able to repair its genetic material (DNA) when it becomes damaged.
- This aspect of the cancer may cause it to be more sensitive - that is, more effectively
killed by certain types of drugs such as the study agent being evaluated in this trial,
Olaparib.
- Olaparib is a type of drug known as a PARP inhibitor. Some types of breast cancer
and ovarian cancer share some basic features that make them sensitive to similar
treatments. Information from those other research studies suggests that this drug
may help to treat metastatic breast cancer.
- This study will evaluate whether olaparib is effective in breast cancer
patients whose tumor has a mutation in one of the other genes that function
with BRCA1 and BRCA2 to repair damaged DNA .This mutation may have been
inherited from a parent, or may have developed only in the tumor.
- This study will also evaluate whether olaparib is effective in breast cancer
patients whose tumor has a mutation in BRCA1 or BRCA2 that was acquired by the
tumor, but not inherited.