Olanzapine Against Delayed Nausea and Vomiting in Women Receiving Carboplatin Plus Paclitaxel
Status:
Unknown status
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
This randomized, pilot study explores the activity of olanzapine with or without delayed
dexamethasone for the prevention of delayed nausea and vomiting in women with gynecologic
cancer receiving the combination of carboplatin and paclitaxel. Women treated with this
regimen are particularly susceptible to chemotherapy-induced nausea and vomiting. Given
anti-emetic prophylaxis with olanzapine may increase the control of delayed symptoms in women
receiving carboplatin and paclitaxel.
Phase:
Phase 2
Details
Lead Sponsor:
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano