Olanzapine Against Delayed Nausea and Vomiting in Women Receiving Carboplatin Plus Paclitaxel

• Status: Unknown status
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: Female

Summary

This randomized, pilot study explores the activity of olanzapine with or without delayed dexamethasone for the prevention of delayed nausea and vomiting in women with gynecologic cancer receiving the combination of carboplatin and paclitaxel. Women treated with this regimen are particularly susceptible to chemotherapy-induced nausea and vomiting. Given anti-emetic prophylaxis with olanzapine may increase the control of delayed symptoms in women receiving carboplatin and paclitaxel.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
• Treatments: Albumin-Bound Paclitaxel; Antiemetics; BB 1101; Carboplatin; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Olanzapine; Paclitaxel; Palonosetron

Criteria

Inclusion Criteria:

• Histologically or cytologically documented gynaecologic cancer

• Patients who are chemotherapy naive and scheduled to receive 1-day moderately emetogenic chemotherapy (carboplatin Area under Curve (AUC) 5 plus paclitaxel).

• Women, 18 years and older

• Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2

• Adequate organ system function, defined as follows:

bone marrow: absolute neutrophil count >=1,500/L, platelets >=100,000/L liver: bilirubin 1.5 x upper limit of normal (ULN); transaminases <=2.5 x ULN kidney: creatinine <=1.5 x ULN

• Able to take oral medications

Exclusion Criteria:

• psychiatric illness or social situation that would preclude study compliance

• history of central nervous system (e.g., brain metastases, seizure disorder)

• Positive pregnancy test just before registration.

• treatment with any anti-emetic medication from 24 hours to 5 days after treatment.

• treatment with another antipsychotic agent such as risperidone, quetiapine, clozapine, phenothiazine, or butyrophenone for 30 days before or during protocol therapy.

• concurrent abdominal radiation therapy.

• concurrent quinolone antibiotic therapy.

• known hypersensitivity to olanzapine.

• vomiting and/or significant nausea (>= Common Toxicity Criteria for Adverse Events (CTCAE) grade 2) within the 24 hours before beginning chemotherapy.

• another organic cause for nausea or vomiting unrelated to chemotherapy administration.

• chronic alcoholism (as determined by the investigator).

• known cardiac arrhythmia, uncontrolled congestive heart failure or acute myocardial infarction within the previous 6 months.

• history of uncontrolled diabetes mellitus.