Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate
Status:
Unknown status
Trial end date:
2008-03-01
Target enrollment:
Participant gender:
Summary
Prostate biopsy is usually conducted transrectal, ultrasonography guided. Since the area is
not sterile, infection can be induced during the procedure.
Prophylaxis antibiotic against gram-negative bacteria decreased significantly the amount of
infections. Quinolones are considered preferred treatment but there is already an increase in
resistance rates. TMP-SMX can not be used empirically due to a high percent of resistant
uropathogens. One of the options is aminoglycosides, especially gentamicin. Advantages: very
low resistance rate in the community, high concentration is urinary tract, slow clearance, no
resistance developed under treatment, chip and with very few side effects.