Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate

• Status: Unknown status
• Trial end date: 2008-03-01
• Target enrollment: 0
• Participant gender: Male

Summary

Prostate biopsy is usually conducted transrectal, ultrasonography guided. Since the area is not sterile, infection can be induced during the procedure.

Prophylaxis antibiotic against gram-negative bacteria decreased significantly the amount of infections. Quinolones are considered preferred treatment but there is already an increase in resistance rates. TMP-SMX can not be used empirically due to a high percent of resistant uropathogens. One of the options is aminoglycosides, especially gentamicin. Advantages: very low resistance rate in the community, high concentration is urinary tract, slow clearance, no resistance developed under treatment, chip and with very few side effects.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: HaEmek Medical Center, Israel
• Treatments: Gentamicins; Levofloxacin; Ofloxacin

Criteria

Inclusion Criteria:

• Patients going under transrectal biopsy of prostate with sterile urine culture.

Exclusion Criteria:

• Urine culture not sterile