Overview

Ofatumumab With IVAC Salvage Chemotherapy in Diffuse Large B Cell Lymphoma Patients

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
It is expected that addition of anti-CD20 antibody - ofatumumab would enhance the activity of the etoposide+ifosphamide with mesna+cytarabine+methotrexate+lenograstim or filgrastim (IVAC) regimen. This study is planned to determine the efficacy and safety of ofatumumab in combination with IVAC chemotherapy in patients with CD20 positive diffuse large B cell lymphoma progressing or relapsed after prior R-CHOP chemotherapy not suitable for Autologous Stem Cell Transplant (ASCT).
Phase:
Phase 2
Details
Lead Sponsor:
Polish Lymphoma Research Group
Treatments:
Antibodies, Monoclonal
Cytarabine
Etoposide
Etoposide phosphate
Lenograstim
Leucovorin
Mesna
Methotrexate
Ofatumumab
Sargramostim