Odansetron and Dexamethasone Alone vs. Odansetron, Dexamethason and Apreptant to Prevent Nausea
Status:
Completed
Trial end date:
2010-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare two different treatment protocols for treating nausea
and vomiting in patients who have undergone bone marrow transplant. Patients will be assigned
to one of two treatment groups.
The first group will recieve ondansetron (Zofran) tablets combined with a medicine called
dexamethasone given IV. Both of these drugs are commercially available.
Patients in the second treatment consists of the first two drugs, plus a newly approved drug
known as aprepitant (MK-869, Emend). This combination will be the treatment being tested. The
combination is approved by the FDA for chemotherapy regimens known to cause a lot of nausea
and vomiting. It significantly decreases the delayed (more than 24 hours after therapy)
nausea and vomiting seen with these regimens.