Ocular Micro-vascular Research Base on Functional Slip Lamp Biomicroscopy
Status:
Unknown status
Trial end date:
2020-06-30
Target enrollment:
Participant gender:
Summary
Dry eye disease (DED), as one of the most common ocular surface diseases that affecting
visual acuity, is highly associated with ocular surface inflammation. Until now, there is no
accurate quantization index system to evaluate real-time ocular surface inflammation.
Besides, an individualized therapy for ocular surface inflammation is also badly needed. As
we all know, conjunctival congestion is one of the important clinical appearance of ocular
surface inflammation. Hence, we suggest that several specific microvascular indexes could
measure the change of ocular surface inflammation. Our program is aiming to investigate the
correlation between inflammatory factors and blood flow velocity as well as microvascular
distribution detecting from bulbar conjunctiva through our own devices and
software.Futhermore, we tend to compare ocular surface microvascular indexes and
microvascular distribution in normal people and dry eye patients in order to establish a
database for Chinese people. By confirming the relationship between ocular surface
microvascular indexes and ocular inflammation, we hope to set up new diagnostic criteria for
ocular inflammation and an individualized therapeutic regimen based on ocular surface
microvascular indexes. Finally, we want to establish a precision diagnostic and therapeutic
pattern for dry eye disease.
Phase:
Phase 4
Details
Lead Sponsor:
Zhongshan Ophthalmic Center, Sun Yat-sen University