Octreotide VS Placebo in Prevention of Salivary Fistulae After Post Radiation Salvage Surgery
Status:
Unknown status
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
Salivary fistulae have been the bane of surgical salvage in the era of primary chemoradiation
for head and neck (H&N) cancers. The "blame"of prior chemoradiation tissue damage encouraged
compensatory surgical techniques that focused on the insertion of non-irradiated tissue into
the field. This study emphasizes a paradigm shift in the understanding and treatment of
pharyngocutaneous fistulae. The detrimental effects of salivary enzymes on tissue healing and
surgical anastomoses are addressed and novel treatment strategy is outlined.