Observation of Propofol Titration at Different Speeds
Status:
Not yet recruiting
Trial end date:
2021-02-14
Target enrollment:
Participant gender:
Summary
Propofol is one of the most widely used anesthetics for its fast onset and quick elimination.
The conventional speed of its induction dose often causes severe hemodynamics fluctuations
with hypotension and arrhythmia. The recommended dosage on the drug insert comes from group
pharmacokinetic studies which does not apply to the specific situation of every patient, so
the investigators emphasize individualized medication. The investigators have observed the
titration of propofol in general anesthesia induction, and found that the dosage was less and
the hemodynamics was becoming more stable. At the same time, the investigators found that the
hemodynamics still has obvious fluctuations in the titration of the administration rate
recommended in the instructions. The investigators intend to further compare the effects of
propofol titration administration at different rates for hemodynamics and stress during the
induction period of general anesthesia, and find a safer and more appropriate rate of
administration.