Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids

• Status: Completed
• Trial end date: 2016-10-22
• Target enrollment: 0
• Participant gender: All

Summary

This project will assess the effectiveness of omega-3 fatty acid supplementation in controlling asthma symptoms among obese asthmatics, and will assess if a person's genes influence response to treatment (personalized medicine). This project may improve our ability to treat asthma and our understanding of the link between obesity and asthma.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nemours Children's Clinic
• Collaborators: National Heart, Lung, and Blood Institute (NHLBI); Office of Dietary Supplements (ODS)

Criteria

Inclusion Criteria:

• age 12-25

• BMI > 25 (age 18-25) or BMI%>85th (age 12-17) (BMI Liberalized)

• Physician diagnosis of persistent asthma

• Lung function responsiveness by bronchodilator reversibility or bronchoprovocation testing

Exclusion Criteria:

• pregnancy

• currently taking LTRA for asthma control

• other serious chronic medical condition

• bleeding diathesis