Obesity, Oral Contraception, and Ovarian Suppression

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study proposes a double blind randomized clinical trial to include normal weight and obese women who have normal ovulatory function at baseline; the investigators will randomize women to 2 widely used OCs and evaluate ovarian follicle development and circulating progesterone to assess ovarian suppression during OC use.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Columbia University
• Collaborator: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
• Treatments: Ethinyl Estradiol

Criteria

Inclusion Criteria:

• Aged 18-35

• Body Mass Index (BMI) 19-24.9 or 30-39.9 kg/m^2

• Willing to take birth control pills for 3-4 months

• Recent spontaneous pregnancy or cyclic menses

Exclusion Criteria:

• Contraindications to hormonal contraceptives

• Oophorectomy/Polycystic ovary syndrome (PCOS)

• Taken oral contraceptives to regulate menses recently

• Weight reduction surgery

• Used Depo-Provera within the last 12 months

• Pregnant or currently breastfeeding

• Desiring pregnancy within the next 4 months

• Unable to make study visit commitment

• Previous participation in this study