OXY-2: The Pharmacogenetics of Oxycodone Analgesia in Human Experimental Pain Models
Status:
Completed
Trial end date:
2007-01-01
Target enrollment:
Participant gender:
Summary
Thirty-two healthy volunteers will be submitted to experimental pain and on the 2 study days
receive Oxycodone 20 mg po vs. placebo. Half of the volunteers will be poor metabolizers
according to CYP2D6 genotype and half will be extensive metabolizers (EM) and have an enzyme
with normal function. The study hypothesis is that PM will experience less pain relief than
EM.